The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Scientists have been searching for an effective ricin antidote for decades. However, cytotoxins like ricin also provide important insights into the molecular characteristics of cells, such as the contact points the poison uses to enter cells.
IMBA researchers have now discovered that sugar is a key factor. The researchers identified two genes that make ricin so lethal. Fut9 and Slc35c1 regulate metabolism of a particular sugar in cells, an essential monosaccharide called fucose.
Renewable resources are gaining special attention as substitutes for petroleum based products. Thus biobased polymers obtained from vegetable oils present a good, green alternative to fossil based polymers in terms of biodegradability and toxicity, thereby allowing their application for high value added and/or biomedical purposes.
In this study, Acyclic Diene Metathesis (ADMET) and thiol-ene miniemulsion polymerization method was followed to synthesize high molecular weight polymers. In addition to the chemical reactions leading to synthesis of high molecular weight polymers, miniemulsion polymerization method enabled the production of polymeric nanoparticles with unique characteristics and vast commercial interest.
Characteristic studies revealed that the synthesized nanoparticles did not present any cytotoxic effect on murine fibroblast (L929) and human cervical cancer (HeLa) cells and showed high blood biocompatibility.
Researchers from India prepared castor oil polyurethane from pre-polymer oftoluene diisocyanate (TDI) and castor oil with dibutyl tin dilaurate (DBTDL) catalyst. Water was used as blowing agent. The rate of forming was increased by increasing catalyst and water content. On other hand the cell size of the PU decreased with increasing amount of the catalyst and water content.
Characterization studies were performed to analyse the properties of synthesized foam.
Scientists from China synthesized hybrid polyurethanes with double-decker silsesquioxane (DDSQ) using castor oil and isophorone diisocyanate (IPDI) as feedstock. Double-decker octaphenyl silsesquioxanetetraol (DDSQ) was prepared and characterized by spectroscopy.
Results showed that with the inclusion of DDSQ, the hydrophobicity of the hybrid material was significantly improved.
Cellulose fibre reinforced composites are considered suitable alternative to plastic products due to the environmental problems caused by the latter. However, pure cellulose fibres have a high hydrophilicity. Moreover, the polar character of these fibres causes their low compatibility with partially or totally hydrophobic polymer matrices.
Owing to the poor wettability and adsorbability towards polymers, the surface modification of the fibres surface is essential, in order to improve the fiber/polymer compatibility and their interfacial adhesion. Hence researchers from France conducted a study to improve the properties of cellulose fibres by modifying the cellulose fibres with trialkoxysilane from castor oil.
Characteristic studies were carried out for the modified cellulose-castor oil polyurethane composites. Results showed that compared with the crude cellulose fibres, the organosilane treatment reduced the hydrophilicity of the natural fibres and increased the fiber/matrix compatibility.
Scientists from India performed esterification of furfuryl alcohol and castor oil fatty acid at 3:1 molar ratio, by immobilized Candida antarctica Lipase B in a solvent free system. A maximum yield of ester was obtained. Performance of the FA-COFA ester plasticized Ethyl Cellulose (EC) films were evaluated by certain characteristic studies.
Results showed that the furfuryl alcohol-castor oil fatty acid ester with significant plasticizing property at a certain concentration could act as a substitute for traditional plasticizer dibutyl phthalate.
Researchers performed an experiment where castor oil, ethyl ester were prepared by transesterification using potassium hydroxide (KOH) as a catalyst and tested on a four-stroke, single-cylinder compression ignition engine. The test was carried out at a constant speed of 3000 rpm at different loads.
The results represent a substantial decrease in carbon monoxide (CO) emission with an increasing biodiesel percentage.
Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. In order to enhance the drug absorption and bioavailability, scientists from India did a research to formulate castor oil based globule.
Results showed that at a certain ratio of castor oil, polyethylene glycol and Tween 20, the formulation had shown uniform globule size, no interactions of LSP with Self Nano Emulsifying Drug Delivery System components and a higher pharmacokinetic parameter than that of commercial preparation.
Ricinoleic acid, derived from castor oil has an anti-inflammatory action following topical application. However ricinoleic acid goes rancid when it is exposed to oxygen. Hence scientists from Egypt performed an experiment to encapsulate ricinoleic acid into ethyl cellulose (EC) electrospun fibres. Electrospinning parameters of EC were optimized to obtain bead-free fibres.
RA at different concentrations was encapsulated into EC fibres. Release profile was reported and encapsulation was demonstrated via morphological analysis.