Dynamics in genetic expression of castor allergen

Gene expression is a phenomenon by which bio-function to be exhibited is emerging from the genetic material of an organism.In this process, bio-systems have developed a property to express them in a regulated way for effective survival,development and energy conservation and regulated gene expression seems to be punched well in higher organisms.People nowadays regularly concentrate on molecular events in diverse biological subjects that are occurring at the cellular level for the differentially expressed biological functions which they witness at the gross morphological level. Progression in plant molecular sciences led to castor seed protein 2s albumin expression as a subject of study today for biologists.2s albumin is an abundant castor seed protein characterized to be potent allergen.

The researchers to address the expression pattern of concerned plant protein made use of different stages of castor seed, developed right after fertilization and exploited a real time expression profiling tool called quantitative polymerase chain reaction.The fingerprint of cDNA transcripts revealed a dynamic pattern in the mode of expression with highest degree of 2s albumin during the middle stages while the presence of it at the initial and maturation phases shows converse levels.The scientists however did not restrict there but proceeded further to generate a profile of active allergen and noticed some degree of relation with transcript.However the allergen contrastingly continued to thrive even after elimination of transcripts which posted an elusive operation of molecular mechanism in castor plant cells for a sustained existence of the allergen,2s albumin as multiple variants.

One thing certain from this study is a correlation between complex intermediary molecular events and phenotypes and hence assists us to better understand and manipulate the traits to our convenience.

For info: http://pubs.acs.org/doi/abs/10.1021/jf071272p

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